Baldwin's first acting role was as Billy Aldrich in the NBC daytime soap opera The Doctors from 1980 to 1982.
In fall 1983, he starred in the short-lived television series Cutter to Houston.
A member of the Baldwin family, he is the eldest of the four Baldwin brothers, all actors.
Baldwin first gained recognition appearing on seasons 6 and 7 of the CBS television drama Knots Landing, in the role of Joshua Rush.
From 2006 to 2013, Baldwin starred as Jack Donaghy on the NBC sitcom 30 Rock, winning two Emmy Awards, three Golden Globe Awards, and seven Screen Actors Guild Awards for his work on the show, making him the male performer with the most SAG Awards. He has received worldwide attention and acclaim for his portrayal of Donald Trump on the long-running sketch series Saturday Night Live, both during the latter part of 2016 U. presidential election campaign and following the inauguration, a role which won him his third Primetime Emmy in 2017.
Baldwin co-starred in Mission: Impossible – Rogue Nation, the fifth installment of the Mission: Impossible series, released on July 31, 2015. Through his father, Baldwin is descended from Mayflower passenger John Howland, and through this line, is the 13th generation of his family born in North America and the 14th generation to live in North America.
Baldwin wrote an episode of Law & Order entitled "Tabloid", which aired in 1998. Barrett Moore, a retired plastic surgeon, in the series Nip/Tuck.
His performance in the 2003 romantic drama The Cooler garnered him a nomination for the Academy Award for Best Supporting Actor.He received his second Emmy nomination for Best Actor in a Television Comedy or Musical as Jack Donaghy in 2008, marking his seventh Primetime Emmy nomination and first win. He also impersonated Republican nominee Donald Trump during SNL's coverage of the 2016 Presidential election, to widespread critical acclaim.In 2017, he won a Primetime Emmy for his portrayal of Trump.The production was taped and telecast by PBS on April 26, 2006.In 2006, Baldwin made theater news in Roundabout Theatre Company's Off-Broadway revival of Joe Orton's Entertaining Mr. In 2010, Baldwin starred opposite Sam Underwood in a critically acclaimed revival of Peter Shaffer's Equus, directed by Tony Walton at Guild Hall in East Hampton, New York.Baldwin also received an Emmy nomination for the 1995 television version of the production, in which both he and Jessica Lange reprised their roles, alongside John Goodman and Diane Lane.In 1998, Baldwin played the title role in Macbeth at The Public Theater alongside Angela Bassett and Liev Schreiber in a production directed by George C. In 2004, Baldwin starred in a revival of Broadway's Twentieth Century about a successful and egomaniacal Broadway director (Baldwin), who has transformed a chorus girl (Anne Heche) into a leading lady.and played football there under Coach Bob Reifsnyder.In New York City, Baldwin worked as a busboy at the disco Studio 54.In 1998, he became the third narrator and George Carlin's replacement for the fifth and sixth seasons of Thomas the Tank Engine & Friends.In 2000, he starred in "Thomas and the Magic Railroad" as Mister Conductor.